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MC38 (Colon Adenocarcinoma)

Description


MC38 (Corbett el al., Can Res, 1975) is a murine colon adenocarcinoma cell line from a C57BL/6 mouse. The cells are adherent and have a fibroblast morphology. MC38 cells will form tumors and metastases post implantation into syngeneic C57BL/6 mice or immunocompromised mice.

Usage Information:


MC38 cells are suitable for in vitro and in vivo experimentation. Both syngeneic C57BL/6 mice and immunocompromised mice can be used for in life studies, and will form tumors following implantation of the cells. 

The following provides some examples of MC38 cells used for tumor formation studies.

Route of Implantation Mice Tumor/Metastases References
Subcutaneously C57BL/6 Subcutaneous tumor
Hos et al. (2020) OncoImmunology, 9:1
Zhu et al. (2017) Nature Communications, 8:154
Tail-Vein C57BL/6 Pulmonary metastases
Kobayashi et al. (2005) Blood, 105:2, 721-727
Zhu et al. (2017) Nature Communications, 8:154

 

Note: The above information is based on available data from the indicated references. It is not meant to be comprehensive and Imanis has not directly tested each condition.

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