Why would I want to use multimodal imaging?

Different reporter genes offer different advantages for imaging studies. By combining multiple reporter genes for multimodal imaging, your study can benefit from the strengths of both imaging modalities or reporter genes. Using different reporter genes is especially helpful when considering the stages of a study from start to finish. For example, fluorescent proteins can be used in vitro during development, Fluc or NIS can be used for in vivo tracking, and iRFP or other fluorescent proteins used for ex vivo imaging to confirm results at the end of the study.