Imanis combines scientific expertise with flexible assay solutions to support every stage of your vector-driven or immune-oncology therapeutic pipeline. From discovery to clinical studies, our team develops and validates assays tailored to your project’s specific needs, ensuring accurate and reliable results.
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At Imanis, we combine deep scientific expertise with agility. Whether you require standard assay services or fully customized solutions, research assays, or fully validated tests, our team works closely with you to meet your timelines, adapt to project requirements, and provide reliable, high-quality data. By partnering with us, you get a collaborative team committed to advancing your research efficiently and effectively.
Vector characterization provides essential data on viral vector quality, concentration, and functional activity, enabling confident assessment of vector integrity and potency. Imanis provides several standard vector characterization assay services, including lentivirus p24 ELISA, nanoparticle tracking analysis (NTA) of lentiviral vectors, and functional titering of lentiviral vectors and replicating VSV. Custom vector characterization services are also available, and whether it’s standard or custom characterization, Imanis delivers reliable, reproducible results.
Cell-based virus neutralization assays are essential for evaluating vector therapies and vaccine efficacy. At Imanis, our experienced virologists develop custom neutralizing antibody (nAb) assays, including pseudovirus reporter gene and PRNT assays, to deliver high-quality, actionable data that support confident decision-making throughout biopharmaceutical development.
Imanis molecular assays provide quantitative insights into viral shedding, viral titer, gene expression, and other critical parameters. With standard digital PCR (dPCR) assay services available for lentiviral vector copy number (VCN) and expertise in developing custom dPCR, qPCR, and RT-PCR assays, Imanis provides key molecular data to support confident decisions throughout the research and development process.
Imanis offers species-specific multiplex cytokine assays to measure circulating cytokine levels across a variety of in vitro and in vivo sample types. These assays support immunotoxicology and safety profiling, analyzing multiple analytes in parallel with high sensitivity and a broad dynamic range. Our team also offers expert interpretation and detailed scientific reporting to help researchers translate results into actionable insights.
Imanis’ immunophenotyping services identify and quantify immune cell populations and evaluate their functional states in vitro and ex vivo. These assays provide essential insights into immune responses, cell subset dynamics, and therapy-induced immunomodulation. With qualified panels, flexible assay platforms, and expert data interpretation, we ensure you gain maximum value from every sample.
We provide critical support for vector biodistribution studies, using both molecular and cell-based assays to detect and quantitate vector levels in tissues collected as part of these studies. Our standard assays for lentiviruses and VSV provide reliable results to track where vectors travel and persist for both pre-clinical and clinical studies.
Our CAR-T cell characterization assays evaluate the phenotype, function, and persistence of engineered T cells in samples from pre-clinical or clinical studies, providing key insights into cell expansion, cytotoxic activity, cytokine secretion, and potential off-target effects. With our extensive expertise in CAR-T cell characterization and established, qualified flow cytometry panels and assays, Imanis offers services tailored to your needs, including comprehensive reporting to translate complex data into actionable insights for cell therapy development.
Imanis also performs CAR-T cell proliferation and killing assays to measure the expansion and cytotoxic activity of engineered T cells in vitro and ex vivo. We have established assay protocols for CD19 and BCMA-targeted CARs and a wide panel of TAA-modified cell lines to support the development of assays for additional CAR targets as needed. We also bring the specialized expertise needed to translate results into meaningful insights on therapeutic potency, functional persistence, and potential off-target effects.
Our vector targeting and specificity assays evaluate cell-specific targeting by engineered vectors/viruses with retargeted viral glycoproteins, providing key insights into on- and off-target delivery. With established cell panels for human CD3 targeting and an extensive catalog of available cell lines, we offer both standard assay services and highly customizable cell panels to support detailed analyses.
Get answers to common questions about assay services from Imanis:
We provide data in clear, organized formats tailored to client needs, including raw files, analyzed datasets, and graphical summaries, depending on the type of assay services requested. As requested, we can combine data from multiple assays into cohesive reports with visual summaries and analysis for a clear, comprehensive view of your study results.
Yes. Our scientific team provides expert interpretation and reporting, helping researchers understand trends, highlight key findings, and translate data into actionable insights.
Turnaround times depend on the type of assay and the level of development needed. For standard assay services, turnaround time is generally one to two weeks but varies depending on the type of assay and the number of samples received. For assay development projects or custom assays, we provide realistic project estimates that factor in project deadlines, assay qualification and/or validation requirements, and assay complexity.
Start by contacting us to share your project and testing needs. For single-instance submissions of standard assay services, we will provide a quote along with sample requirements and shipping information. For customized, new, or longitudinal assay services, one of our assay scientists will follow up to discuss your needs in depth. You will then receive a statement of work outlining the proposed scope, assay strategy, timelines, and pricing.
We accept a variety of samples depending on the type of assay services requested, including in vitro cell cultures; crude and/or purified vector preparations; blood, serum, plasma, and tissue samples from multiple species; and extracted nucleic acid samples.
Yes. Most of our standard assays are designed for human, mouse, or purified vector materials. But we can customize and develop assays for additional preclinical species upon request.
Yes. We support repeat testing and longitudinal studies to ensure that you receive consistent, high-quality data across long-term studies or different study phases. Contact us about your needs, and we can discuss setting up a longitudinal sample testing plan.
Our well-qualified assays produce reproducible, reliable data, and many are designed with preclinical and translational requirements in mind. Custom assays are developed to user requirements, whether that is research-level or fully validated assays. We can provide documentation to support regulatory decision-making upon request.
Contact us to tell us your research goals and we’ll get back to you with how we can best support you.
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