Imanis offers tumor cell line models for studies of multiple myeloma and BCMA-targeted therapies. These models have characterized BCMA expression combined with stable reporter expression for cell tracking in vivo.
B-cell maturation antigen (BCMA), also known as TNFRSF17 or CD269, is a cell surface receptor of the TNF receptor superfamily. It is primarily expressed in mature B cells and plasma cells, with little expression observed in hematopoietic stem cells or nonhematopoietic cells. BCMA, along with its ligands BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand) are critical for survival of long-lived plasma cells. Cleavage of BCMA by endogenous γ-secretase, releases soluble BCMA that can be detected in the blood and acts as a decoy for BAFF and APRIL, leading to reduced activation of cell surface BCMA.
BCMA is both a marker and therapeutic target for multiple myeloma. It is highly expressed on malignant plasma cells in both newly diagnosed and relapsed/refractory multiple myeloma patients, and higher levels of soluble BCMA are present in the blood of these patients. Currently, numerous BCMA-targeted therapeutics – including bispecific antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) T-cells – are under development or have already been clinically approved for treatment of multiple myeloma.
Cell lines can be purchased individually or at a discounted rate for pairs/panels.
| Product | BCMA Expression | Price | Purchase |
|---|---|---|---|
| K562-Fluc-Puro | Naturally negative for BCMA | $2,500 | Add Item |
| K562-Fluc-Puro/BCMA-Puro | Overexpress BCMA | $3,000 | Add Item |
| K562-Fluc-Puro and K562-Fluc-Puro/BCMA-Puro | $5,000 | Purchase Pair | |
| U266B1-Fluc-Puro | Naturally BCMA positive | $2,500 | Add Item |
| U266B1-Fluc-Puro/eGFP-Neo | Naturally BCMA positive | $3,000 | Add Item |
| RPMI-8226-Fluc-Puro | Naturally BCMA positive | $2,500 | Add Item |
| RPMI-8226-Fluc-EmGFP | Naturally BCMA positive | $3,000 | Add Item |
Don’t see what you need in our catalog? Our scientific team engineers cell lines, viral vectors, and assays and provides as much characterization data as you need to move forward with confidence.
