C1498 (ATCC® TIB-49™) is a murine myeloid leukemia cell line isolated from a C57BL/6J mouse. It most closely resembles acute myeloid leukemia (AML), and is highly lethal when implanted into syngeneic mice.
*The ATCC trademark and trade name and any and all ATCC catalog numbers are trademarks of the American Type Culture Collection.
| Route of Implantation | Mice | Tumor/Metastases | References |
|---|---|---|---|
| Intravenous | C57BL/6 | Bone marrow, liver, lymph nodes, ovary, subcutaneous masses, spleen, skin, kidney, and central nervous system | Boyer, et al. (1995) Blood 85: 2498-2506Zhang, et al. (2009) Blood 114: 1545-1552Sauer et al. (2004) Cancer Res 64: 3914-3921 |
| Subcutaneous | C57BL/6 | Subcutaneous tumor | Boyer et al. (1997) Blood 89: 3477-3485 |
Our C1498 reporter cell lines can be tracked in vivo, making them great tools for studying the mechanisms of tumor growth and metastasis, as well as evaluating the effects of various drugs or therapies in animals. Our C1498 cells are available with firefly luciferase (Fluc) or enhanced green fluorescent protein (eGFP). Dual reporter cell lines are available to facilitate multimodal imaging.
In order to ensure high, constitutive expression of the reporter proteins, our cell lines are generated by lentiviral vector transduction. The lentiviral vectors used for these transductions are self-inactivating (SIN) vectors in which the viral enhancer and promoter has been deleted. This increases the biosafety of the lentiviral vectors by preventing mobilization of replication competent viruses (Miyoshi et al., J Virol. 1998).
Don’t see what you need in our catalog? Our scientific team engineers cell lines, viral vectors, and assays and provides as much characterization data as you need to move forward with confidence.
