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What is the source of the transgenes?

Our transgenes come from a variety of sources. Check out the table below for detailed information about the source of our transgenes.

Transgene Accession # Gene Source Description
Luc2 AY738222 Photinus pyralis Codon optimized firefly luciferase with brighter signal1.
hNIS U66088 Homo sapiens Human sodium iodide symporter; mediates iodide uptake2.
hNISplus Mutant of

U66088

Homo sapiens Genetically modified hNIS with enhanced radiotracer uptake.
mNIS  AF235001 Mus musculus Murine (mouse) sodium iodide symporter; mediates iodide uptake3.
rNIS  U60282.1 Rattus norvegicus Rat sodium iodide symporter; mediates iodide uptake4.
pigNIS  NM214410 Sus scrofa Pig sodium iodide symporter; mediates iodide uptake5.
RhNIS N/A* Rhesus macaque Rhesus sodium iodide symporter; mediates iodide uptake.
dNIS XM_541946 Canis lupus Dog sodium iodide symporter; mediates iodide uptake6.
IRES M81861

(nt 260 to 848)

EMCV Internal ribosome entry site; RNA element that mediates internal translation initiation7.
eGFP  AAB02572.1 Variant of GFP from Aequorea victoria Enhanced GFP; mutant of GFP with a 100-fold increase in fluorescent signal8.
iRFP JN247409 Rhodopseudomonas palustris Near-infrared fluorescent protein; red-shifted fluorescent protein with an excitation/emission of 690/713 nm9.
dsRed  AB212907 Anopheles gambiae Red fluorescent protein variant with an excitation/emission of 558/583 nm10.
DRD2 NM_016574.3 Homo Sapiens Dopamine receptor D2; endogenously expressed in the brain11.
hNET NM_001172501.1 Homo Sapiens Human norepinephrine transporter; endogenously expressed by noradrenergic neurons12.
SSTR2 AY236542.1 Homo Sapiens Somatostatin receptor 2; endogenously expressed in cerebrum and kidneys13.
HSV-TK JQ352282.1 HSV Human herpesvirus 1 thymidine kinase (UL23)14.
hTYR M27160.1 Homo sapiens Tyrosinase; converts tyrosine to brown-pigmented melanin15.

*Sequence derived from a cDNA library. Email support@imanislife.com for more information.
1 Promega
2 Smanik et al. Biochem Biophys Res Commun. 1996. 226(2):339-45
3 Pinke et al. Thyroid. 2001. 11(10):935-9
4 Dai et al. Nature. 1996. 379(6564):458-60
5 Selmi-Ruby et al. Endocrinology. 2003. 144(3):1074-85
6 Uyttersprot et al. Mol Cell Endocrinol. 1997. 131(2):195-203
7 Gurtu et al. Biochem Biophys Res Commun. 1996. 229(1):295-8
8 Cormack et al. Gene. 1996. 173(1):33-8
9 Filonov et al. Nat Biotechnol. 2011. 29(8):757-61
10 Baird et al. Proc Natl Acad Sci USA. 2000. 97(22):11984-9
11 Dearry et al. Cell Mol Neurobiol. 1991. 11(5):437-53
12 Pacholczyk et al. Nature. 1991. 350(6316):350-4
13 Parry et al. Mol Imaging. 2007. 6(1):56-67
14 Koehne et al. Nat Biotechnol. 2003. 21(4):405-13
15 Takeda et al. Biochem Biophys Res Commun. 1989. 162(3):984-90

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