What is NIS? How do I image it?

NIS is the sodium iodide symporter. It is a membrane protein that drives uptake of iodine into cells. Mammals express NIS endogenously in certain tissues. Target cells and viruses can be engineered to express NIS. NIS concentrates several SPECT and PET radiotracers, and as such, cells or viruses expressing NIS can be imaged using nuclear imaging. For more information about NIS, when to use NIS imaging, and which radiotracers to use to image NIS, visit our Discover NIS page.