EMT6 (mammary carcinoma)
EMT6 (ATCC® CRL-2755™) is a murine mammary carcinoma cell line derived from a transplanted hyperplastic alveolar nodule of a BALB/c mouse1. In syngeneic mice, EMT6 cells form tumors and spontaneous metastases, primarily to the lungs2,3. More recently, EMT6 has emerged as a valuable pre-clinical model for immuno-oncology studies of triple negative breast cancer. EMT6 tumors express PD-L1 and are moderately responsive to immunotherapies. Individual checkpoint inhibitors (anti-CTLA-4 or anti-PD-L1) generally have modest effect on tumor growth, while combination therapies exhibit greater success4-7, making EMT6 a beneficial model for combination therapy studies.
Imanis EMT6 Reporter Cell Lines
- Facilitate in vivo tracking using firefly luciferase (Fluc)
- Expedite precise post mortem analysis using enhanced green fluorescent protein (eGFP)
- Stably express* high-levels of reporter genes for bright detection of less cells.
* Imanis cell lines are generated by lentiviral vector transduction with self-inactivating (SIN) vectors8.
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- Lewis et al (2018) Oncoimmunology. 7: e1377873.
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